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redmanjp wrote:Can u give an example of a long term effect which has happened years after a vaccine which had been proven to be caused by it.?
Yawnn....Go take your booster bro like a nice sheep, don't worry things will get back to normal when you take your 7th shotst7 wrote:"case closed" "talk done"
you think u smart that anything u say is a fact and u ultimately right? only jammette does act so ignant boss.
take it down - u just a piece of sheit who dont know sheit. humble yuhself
hover11 wrote:If they are so safe, why no one standing liability? Case closed...why these multi billion dollar companies not standing behind their finished products ?
meccalli wrote:redmanjp wrote:Can u give an example of a long term effect which has happened years after a vaccine which had been proven to be caused by it.?
Extremely rich history of issues with vaccines inducing enhanced infections as a result of exposure to future reinfections by variants. It's a trojan horse effect caused by vaccination which may initially protect but subsequently enhance infection. ADE was noted in Sars cov1 as well as Dengue, Ebola, Aids etc..which is why they've all failed so far.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377703/
SARS coronavirus has antibody-dependent enhancement (ADE) effect through the autologous antibodies against envelope spikes on Fcγ receptor expressing cells
We suggested that antibodies against spike proteins of SARS-CoV may cause ADE effect. This data raises reasonable concern regarding the use of SARS-CoV vaccine and shed light on some roles in SARS pathogenesis.
The Improbability of the Rapid Development of a Vaccine for SARS-CoV-2
https://www.cell.com/molecular-therapy- ... 25-0016(20)30295-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1525001620302951%3Fshowall%3Dtrue
ADE is a phenomenon whereby antibodies bind to the targeted virus and then the resulting antibody/virus complex enhances uptake of the virus by host macrophages and other immune cells. ADE was originally observed with Dengue virus infection and also in the coronavirus feline infectious peritonitis virus (FIPV).2 A relatively overlooked body of ∼40 years of research exists with cats and coronaviruses. Cats infected with FIPV experience dry and wet forms of disease that ultimately result in serious pathologies, including respiratory and neurological issues that are usually fatal.2 Moreover, in cats, it is well known that immunization with feline coronavirus spike protein leads to ADE and, in general, the worsening of infection upon exposure to infectious virus.3, 4, 5 Interestingly, in cats infected with FIPV, the expression of ORF7 has been found to be required for macrophage infectivity and ADE, suggesting that coronaviruses have evolved molecular mechanisms to modulate macrophages.6 Indeed, ADE has been observed to date in several coronaviruses, including CoV-17,8 and Middle East respiratory syndrome (MERS),9 and, notably, Orf7 is present in the genomes of both Cov-1 and Cov-2,10 ultimately suggesting that macrophages are involved in the basic biology of coronaviruses and ADE. Collectively, what is apparent is that the evolutionary adaptation of ADE by coronaviruses to infect macrophages as a means to not only replicate in these immune cells, but to also disseminate the virus infection distal from the lungs,1 represents a bona fide and largely underappreciated challenge to antibody-based therapeutics and, in particular, the development of a humoral-based vaccine.
There is little doubt that humankind would love nothing more than to have a viable vaccine to CoV-2. However, there are objective realities for why we do not yet have a vaccine for coronaviruses in cats, Dengue, Ebola, and HIV in humans, and this is because all of these viruses induce some level of ADE. Moreover, it is exceedingly challenging to dissect and control an immune system that has co-evolved with viruses for millions of years. It is for these reasons, based on an abundance of previously published studies on ADE and coronaviruses, that I am concerned by the lack of focus and/or concerted efforts toward the rapid development of therapeutics specifically tailored for CoV-2. Coronaviruses are susceptible to RNA interference,11,12 antisense RNA, and oligonucleotide therapeutics,13, 14, 15 suggesting that both cellular and molecular gene and cell therapies could prove quite useful in treating coronavirus infections. What is important to note is that therapies exist that can generally work in a relatively short period of time and can be tailored to specifically target the virus at a fraction of the cost of a vaccine. It is not surprising that there is much hope for a vaccine to end this pandemic in a single shot so that we can all return to the “old normal,” but there are, however, regrettably objective realities in biology, and ADE is one of them.15 This is not to say ADE cannot be overcome, but rather that it should heavily factor into the equation in the development of a viable vaccine for Cov-2 and coronaviruses in general. The exceedingly difficult past ∼35 years of challenges in trying to develop a vaccine for HIV have made clear to me that we should strive for the penultimate goal of a vaccine but always have a therapy in our back pocket.
Secondly, the issues with a vaccine that don't produce sterilizing immunity or are considered leaky, as characterized in the problems that's plagued the chicken industry until they developed one that was effective at preventing infection.
https://www.nationalgeographic.com/scie ... en-viruses
Leaky Vaccines Enhance Spread of Deadlier Chicken Viruses
This problem, where vaccination fosters the evolution of more virulent disease, does not apply to most human vaccines. Those against mumps, measles, rubella, and smallpox are “perfect:” They protect against disease and stop people from transmitting the respective viruses. “You don’t get onward evolution,” says Read. “These vaccines are very successful, highly effective, and very safe. They have been a tremendous success story and will continue to be so.”
He is more concerned about the next generation of vaccines that are being developed against diseases like HIV and malaria. People don’t naturally develop life-long immunity to these conditions after being infected, as they would against, say, mumps or measles. This makes vaccine development a tricky business, and it means that the resulting vaccines will probably leak to some extent. “This isn’t an argument against developing those vaccines, but it is an argument for ensuring that we carefully check for transmission,” says Read.
“The candidate Ebola vaccines are also foremost in my mind,” he adds. “Some of the monkey trials suggest that they may be perfect, but we need to be very confident that they don’t leak. If they do, and some vaccinated individuals are capable of passing on Ebola, that might lead to the evolution of very dangerous pathogens.”
https://www.pbs.org/newshour/science/tt ... -dangerous
This chicken vaccine makes its virus more dangerous
. Chickens vaccinated against Marek’s disease rarely get sick. But the vaccine does not prevent them from spreading Marek’s to unvaccinated birds.
“With the hottest strains, every unvaccinated bird dies within 10 days. There is no human virus that is that hot. Ebola, for example, doesn’t kill everything in 10 days.”
In fact, rather than stop fowl from spreading the virus, the vaccine allows the disease to spread faster and longer than it normally would, a new study finds. The scientists now believe that this vaccine has helped this chicken virus become uniquely virulent. (Note: it only harms fowl). The study was published on Monday in the journal PLOS Biology.
This is the first time that this virus-boosting phenomenon, known as the imperfect vaccine hypothesis, has been observed experimentally.
The reason this is a problem for Marek’s disease is because the vaccine is “leaky.” A leaky vaccine is one that keeps a microbe from doing serious harm to its host, but doesn’t stop the disease from replicating and spreading to another individual. On the other hand, a “perfect” vaccine is one that sets up lifelong immunity that never wanes and blocks both infection and transmission.
It’s important to note childhood vaccines for polio, measles, mumps, rubella and smallpox aren’t leaky; they are considered “perfect” vaccines. As such, they are in no way in danger of falling prey to this phenomenon.
But the results do raise the questions for some human vaccines that are leaky – such as malaria, and other agricultural vaccines, such as the one being used against avian influenza, or bird flu.
Good news I suppose is that BBIBP-CorV (sino) when tested in macaques, showed no sign of ADE occurring, however it was stated that caution should be taken to evaluate it properly based on the history of SARS producing this effect.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275151/
Development of an Inactivated Vaccine Candidate, BBIBP-CorV, with Potent Protection against SARS-CoV-2
Inactivated vaccines are widely used for the prevention of emerging infectious diseases (Stern, 2020), and the relatively high speed of the development of this kind of vaccine makes it a promising strategy for COVID-19 vaccine development. It is worthy to note that emerging evidence has shown antibody-dependent enhancement (ADE) in SARS-CoV infection (Wang et al., 2016, Yang et al., 2005), suggesting that particular attention should be paid to the safety evaluation in the development of the vaccine against coronaviruses.
Based on the result presented here, a Phase I clinical trial of BBIBP-CorV is currently in progress and a Phase II clinical trial has recently been initiated. These clinical trials have been designed using the same aluminum adjuvant formulation described here, with three different groups of high, medium, and low dose groups to evaluate the appropriate dose for further clinical application. Published online 2020 Jun 6
This is why vaccine development and safety evaluation takes so much time, it cannot be assessed by parallel means. Vaccine associated enhanced disease tends to rear its head under specific conditions, usually down the road when a particular variant is allowed to infect the host much more easily as a result of the conditioning the immune system develops by means of a a poorly designed vaccine.
Potential pathways of aggravation of SARS‐CoV‐2 infection by ADE. Initially, the spike protein of SARS‐CoV‐2 binds through the RBD to angiotensin‐converting enzyme 2 (ACE2) on the host cell surface for virus invasion. After some days, humoral responses develop against the virus, eliminating infection through allosteric and neutralizing antibodies (NAbs). After a second infection with the same SARS‐CoV‐2 strain virus destruction may occur, if the NAb titer is high enough. However, in case of a low NAb titer, ADE may be observed following binding of the SARS‐CoV‐2/antibody complex to ACE2, internalization of the complex and IgG induced stimulation. In addition, immunized patients may be re‐infected with a different SARS‐CoV‐2 strain, such as a RBD‐mutated strain. In this context, already existing Abs could bind with reduced affinity to mutated RBD, inducing low levels of SARS‐CoV‐2/antibody complexes, following by internalization through the ACE2 receptor and ADE . On the other hand, immunized patients re‐infected by an RBD‐mutated strain may present sufficient Ab blockade of the heterotypic SARS‐CoV‐2 strain. In this case, SARS‐CoV‐2 covered by Abs may connect to Fcγ receptors II (FcγRII) on the surface of B cells or other professional antigen‐presenting cells (APCs). This receptor mediates SARS‐CoV‐2 invasion into immune cells, further spreading viral infection into all organs and ADE.
Funny enough this article postulated if it were to happen, it's most likely to occur with China's innactivated vaccine, yet they've been the most transparent, meanwhile pfizer wants 97 years to release the data they submitted and used to evaluate and approve EUA application of their product.
https://www.medpagetoday.com/special-re ... ives/91648
Why ADE Hasn't Been a Problem With COVID Vaccines
hover11 wrote:Yawnn....Go take your booster bro like a nice sheep, don't worry things will get back to normal when you take your 7th shotst7 wrote:"case closed" "talk done"
you think u smart that anything u say is a fact and u ultimately right? only jammette does act so ignant boss.
take it down - u just a piece of sheit who dont know sheit. humble yuhself
This is same guy that doesn't know our watch words you expected anything more?88sins wrote:Did I just watch deyalsingh spell the word "refrane"?
Yes I did
hover11 wrote:Haiti has a vaccine uptake of 1%. That's right, with a population of 11.4 million souls. Total deaths since pandemic started- 780 souls. So why TnT with a population of 1.4 million and vaccine uptake of 48% has over 3000 dead? Maths not mathsing
The_Honourable wrote:hover11 wrote:Haiti has a vaccine uptake of 1%. That's right, with a population of 11.4 million souls. Total deaths since pandemic started- 780 souls. So why TnT with a population of 1.4 million and vaccine uptake of 48% has over 3000 dead? Maths not mathsing
Interesting...
Haiti’s dramatically low Covid count and death rate may be a combination of the government’s poor record keeping, and not enough testing sites. https://www.local10.com/news/local/2021 ... -in-haiti/
Last June, the country of 11 million was hit with a significant wave of infections. Hospital wards filled with COVID-19 patients. At the time, the country only had two places that could test for the virus, so the actual number of infections is unknown.
https://www.npr.org/sections/goatsandso ... -death-rat
pugboy wrote:we don’t hear much of carpha and testing anymore
bluefete wrote:Hover, my brother, I really hope you do not get Covid-19.
https://www.dailymail.co.uk/news/articl ... amage.html
https://www.newsweek.com/covid-penis-sh ... on-1669045
Same thing I saying all these side effects , nobody, both vaccinated and unvaccinated knows how covid will affect them.Same can be Said with the vaccines yes side effects happen but honestly no doctor can give an all clear for vaccination because yes they may know your medical history but they don't know how it's going to react to your body. My opinion is everyone has a free choice to make it's either they want it or not...no one should be force to do things they don't want to...Mmoney607 wrote:bluefete wrote:Hover, my brother, I really hope you do not get Covid-19.
https://www.dailymail.co.uk/news/articl ... amage.html
https://www.newsweek.com/covid-penis-sh ... on-1669045
well then there should be hundreds of millions like this. Let's do a poll (no pun intended) of tuner men that have gotten covid, some twice, and see if they confirm.
hover11 wrote:Same thing I saying all these side effects , nobody, both vaccinated and unvaccinated knows how covid will affect them.Same can be Said with the vaccines yes side effects happen but honestly no doctor can give an all clear for vaccination because yes they may know your medical history but they don't know how it's going to react to your body. My opinion is everyone has a free choice to make it's either they want it or not...no one should be force to do things they don't want to...Mmoney607 wrote:bluefete wrote:Hover, my brother, I really hope you do not get Covid-19.
https://www.dailymail.co.uk/news/articl ... amage.html
https://www.newsweek.com/covid-penis-sh ... on-1669045
well then there should be hundreds of millions like this. Let's do a poll (no pun intended) of tuner men that have gotten covid, some twice, and see if they confirm.
adnj wrote:Updated.
paid_influencer wrote:adnj wrote:Updated.
calling this chit out
no source. that data doesn't exist. pure made up crap.
and figures can't be boiled down to a single number like that anyway. protection against infection or severe disease moves with time since vaccination and the trajectory changes for different age groups.
no source. that data doesn't exist. pure made up crap.
figures can't be boiled down to a single number like that anyway.
protection against infection or severe disease moves with time since vaccination and the trajectory changes for different age groups
hover11 wrote:Coronavirus digest: Fourth booster 'not enough' to fight omicron, study shows
Early data out of Israel suggests that a fourth dose of either the Pfizer/BioNTech or Moderna coronavirus vaccine can bring an increase in antibodies — more than what's been seen after a third dose — but it still might not be enough to protect against breakthrough infections caused by the Omicron variant.
https://www.google.com/amp/s/amp.dw.com ... a-60454680
At some point I’m afraid a lot of people are going to realize they have been lied to
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